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The Relation of Thrombokinetics to Bone Marrow Megakaryocytes and to the Size of the Spleen in Polycythaemia Vera
Author(s) -
Kutti Jack,
Ridell Börje,
Weinfeld Aleksander,
Westin Jan
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00045.x
Subject(s) - polycythaemia , spleen , mean platelet volume , platelet , megakaryocyte , bone marrow , blood volume , medicine , endocrinology , haematopoiesis , chemistry , immunology , biology , microbiology and biotechnology , stem cell
Platelet kinetics, volume of megakaryocytes per μ l sternal bone marrow, and the volume of the spleen have been quantitated in 20 cases of untreated polycythaemia vera (PV). There was a very good relationship between platelet production rate and megakaryocyte volume/μl bone marrow. The results suggest that megakaryopoiesis in PV represents mainly an effective platelet production. The megakaryocyte volume/μl bone marrow was significantly related to the body platelet mass (p < 0.001), but its relationship to the peripheral platelet count was significant only at the 10 % level. This was due to altered platelet distribution caused by differences in spleen and blood volumes. There was a negative relationship between platelet half‐life time (T 1/2) and spleen volume (0.10 > p > 0.05) suggesting that enlargement of the spleen as such influences platelet survival. A highly significant correlation between platelet production rate and spleen volume, as well as between body platelet mass and spleen volume was found. The influence of the spleen size on platelet kinetics in PV has been discussed.