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Immunologic Studies in Haemophilia A
Author(s) -
Holmberg L.,
Nilsson I. M.
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00032.x
Subject(s) - haemophilia , haemophilia a , heterologous , antiserum , cryoprecipitate , antigen , haemophilia b , medicine , coagulation , immunology , factor ix , antibody , virology , biology , platelet , surgery , genetics , gene
The defect in haemophilia A may be due to the absence or deficiency of factor VIII or to the formation of a defective factor VIII. With the use of both an inhibitor neutralising test and a heterologous antiserum against factor VIII 44 patients with haemophilia A were studied for factor VIII related antigenic material in plasma. All the patients had a factor VIII related protein, immunochemically demonstrable with rabbit antiserum but only 4 patients with mild haemophilia A, all belonging to the same family, could neutralise a human inhibitor. 4 patients with haemophilia A and a circulating anticoagulant also had antigenic material. In 1 patient without haemophilia but with an anticoagulant against factor VIII the level of the factor VIII related protein was high.