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Fibrinolytic Activity of Human Synovial Membranes in Health and in Haemophilia
Author(s) -
PANDOLFI M.,
AHLBERG Å.,
TRALDI A.,
NILSSON I. M.
Publication year - 1972
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1972.tb00988.x
Subject(s) - fibrinolysis , haemophilia , pathogenesis , haemophilia a , hemarthrosis , synovial membrane , medicine , coagulation , pathology , immunology , surgery , inflammation
Examination of the fibrinolytic activity of human healthy and haemophilic synovia with a histochemical technique permitting localisation and assay of fibrinolytic activity clearly revealed fibrinolytic activity confined to the cells forming the synovial lining and to the underlying blood vessels. The strength of fibrinolytic is undiminished in the hypertrophic haemophilic synovial membranes. The findings lend support to the assumption that local fibrinolysis plays an important role in the pathogenesis of intraarticular haemorrhage in haemophilia.