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Dysfibrinogenaemia Associated with Primary Hepatoma
Author(s) -
VERHAEGHE R.,
DAMME B.,
MOLLA AYESHA,
VERMYLEN J.
Publication year - 1972
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1972.tb00968.x
Subject(s) - fibrinogen , prothrombin time , partial thromboplastin time , fibrin , thrombin time , autopsy , coagulation , thromboplastin , pathology , chemistry , thrombin , medicine , endocrinology , immunology , platelet
A coagulation defect, characterised mainly by a prolongation of the thrombin time, the prothrombin time and the partial thromboplastin times was discovered in a patient with severe liver damage. As the reptilase time was also prolonged and a discrepancy was found between fibrinogen determinations in plasma with different methods the presence of an abnormal fibrinogen was postulated. After purification of fibrinogen from the plasma, a delayed aggregation of fibrin monomers was confirmed. Histological examination of the liver at autopsy revealed the existence of a primary hepatoma, suggesting the acquired nature of the abnormal molecule.