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Mechanisms Underlying 6‐Methyl‐Prednisolone Influences on Erythropoiesis
Author(s) -
PESCHLE CESARE,
ZANJANI ESMAIL D.,
SASSO GUIDO F.,
RAPPAPORT IRA A.,
GORDON ALBERT S.,
CONDORELLI MARIO
Publication year - 1972
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1972.tb00967.x
Subject(s) - erythropoiesis , erythropoietin , endocrinology , medicine , prednisolone , chemistry , hypoxia (environmental) , pharmacology , anemia , organic chemistry , oxygen
The administration of 6‐methyl‐prednisolone hemisuccinate (MPH) in ex‐hypoxic polycythaemic mice elicited a significant stimulatory effect on the rate of erythropoiesis. Thus, a 4 to 10‐fold increase was induced by dose levels comparable to those employed in the treatment of aplastic anaemias and pure red cell aplasias. This erythropoietic response was completely abolished by simultaneous administration of anti‐erythropoietin (anti‐Ep) serum. Additionally, MPH did not potentiate the wave of erythropoiesis evoked by exogenous Ep. Consequently, the stimulatory effect of MPH is apparently mediated by increased Ep production, rather than an influence on Ep kinetics or its effect on erythropoiesis. In support to this contention, MPH induced a synergistic enhancement of both the erythropoietic response and the Ep plasma titers evoked by hypoxia. In addition, the erythropoietic effect of MPH was evaluated in polycythaemic mice at various time intervals after a single injection. The response was similar to that observed when exogenous Ep was given. However, with MPH, the effect was delayed for about 24 h. Finally, it is of pharmacological interest that administration of large dose levels of MPH (2 to 8 mg) in normal mice resulted in a significant inhibition of erythropoiesis.