Premium
Fibrinaemia and Multiple Thrombi in Pancreatic Carcinoma: A Case Studied with Quantitative N‐Terminal Analysis
Author(s) -
KIERULF P.,
GODAL H. C.
Publication year - 1972
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1972.tb00954.x
Subject(s) - fibrinogen , fibrin , thrombin , blood proteins , proteases , in vivo , chemistry , coagulation , medicine , pathology , biochemistry , immunology , biology , enzyme , platelet , microbiology and biotechnology
In a 64‐year‐old man several thrombo‐embolic episodes occurred in spite of oral anticoagulant treatment with Thrombotest values below 10%. Normalization of a low plasma fibrinogen, cryofibrinogen and the ethanol gelation test during heparin treatment, suggested chronic intravascular coagulation several weeks prior to the recognition of a pancreatic carcinoma. N‐terminal analysis of the clottable plasma proteins established that about 11 % of the plasma fibrinogen existed as soluble fibrin in plasma. Such a large amount of soluble fibrin suggests the joint action of thrombin and other proteases on the clottable proteins in vivo.