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Serum Myeloperoxidase in Leukaemia and Polycythaemia vera
Author(s) -
MALMQUIST JÖRGEN
Publication year - 1972
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1972.tb00946.x
Subject(s) - polycythaemia , myeloperoxidase , ouchterlony double immunodiffusion , granulocyte , promyelocyte , immunology , medicine , immunodiffusion , myelocytic leukemia , polycythemia vera , myeloid , leukemia , antibody , inflammation , antiserum
Myeloperoxidase is a haem enzyme which is a characteristic constituent of the neutrophil granulocyte series and of monocytes. Using myeloperoxidase purified from human granulocytes and myelocytes, a radio‐immunodiffusion method for the measurement of this protein has been developed. Normal sera were found to contain only traces (up to 2 mg/l) of myeloperoxidase. Elevated concentrations (up to above 10 mg/l) were found in some patients with acute leukaemia, monocytic leukaemia, and chronic myelocytic leukaemia. Minor elevations occurred in 5 of 13 cases of polycythaemia vera. The findings are discussed in relation to current knowledge on the synthesis and intracellular localization of myeloperoxidase.