Premium
Morphology, Dipeptidases and Disaccharidases of Small Intestinal Mucosa in Vitamin B 12 and Folic Acid Deficiency
Author(s) -
BERG N. O.,
DAHLQVIST A.,
LINDBERG T.,
LINDSTRAND K.,
NORDÉN Å.
Publication year - 1972
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1972.tb00927.x
Subject(s) - disaccharidase , dipeptidase , medicine , folic acid , endocrinology , gastroenterology , enzyme , chemistry , biochemistry , small intestine
Mucosal morphology and intestinal enzyme activities (dipeptidases and disaccharidases) were studied in 33 biopsies from 24 patients with vitamin B 12 and/or folic acid deficiency. The villi were generally shorter in patients than in controls (34 subjects). The disaccharidases and L‐alanyl‐L‐proline dipeptidase activity were depressed in about 30 % of the patients, untreated and treated. Glycyl‐L‐leucine and L‐alanyl‐L‐glutamic acid dipeptidase activity was normal in untreated patients but was depressed during treatment with vitamin B 12 .