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Effects of an Enlarged Splenic Platelet Pool in Hodgkin's Disease
Author(s) -
ABRAHAMSEN ARNE FOSS
Publication year - 1972
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1972.tb00925.x
Subject(s) - splenectomy , spleen , thrombocytosis , platelet , medicine , gastroenterology , immunology , surgery
Platelet survival studies with a 51 Cr‐labelling technique were carried out in patients with untreated Hodgkin's disease before and after splenectomy. The result have shown that: (1) platelet recovery increased from 30 % to 90 % after splenectomy, indicating a considerable pooling of platelets in the spleen; (2) the splenic platelet pool increased with increasing spleen weight; (3) platelet survival was not affected by splenectomy except for a transitory shortening in the postoperative phase; (4) the thrombocytosis after splenectomy increased with the weight of the removed spleen and may, to a large part, be due to removal of a splenic platelet pool.