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Adenosine‐Triphosphatase Deficiency in a Family with Non‐Spherocytic Haemolytic Anaemia
Author(s) -
HANEL H. K.,
COHN J.
Publication year - 1972
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1972.tb00910.x
Subject(s) - adenosine triphosphatase , adenosine triphosphate , atpase , chemistry , medicine , endocrinology , biology , enzyme , biochemistry
A family with depressed ATP‐ase activity in erythrocytes is examined. The deficiency was in some members of the family accompanied by non‐sperocytic haemolytic anaemia. Biochemical investigations indicate that digoxin‐sensitive ATP‐ase is reduced, in some cases to zero in presumably homozygotes. It is concluded that the ATP‐ase deficiency is probably due to reduced synthesis of the K, Na, Mg‐stimulated ATP‐ase.