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Urinary Excretion of Histamine and Histamine Metabolites in Leukaemia
Author(s) -
Berg Bertel,
Granerus Göran,
Westling Håkan,
White Thomas
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb02672.x
Subject(s) - histamine , urine , excretion , urinary system , chemistry , endocrinology , medicine
Most patients with chronic myelocytic leukaemia (12 cases in this material) excreted much larger quantities (up to twenty times normal) of histamine metabolites in the urine than healthy individuals and patients with other forms of leukaemia. This indicated an increased rate of formation of histamine in chronic myelocytic leukaemia. The site and mechanism of this increased histamine formation is discussed in relation the metabolic pattern found.