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Cell Cycle Effect of Extracorporeal Irradiation of the Blood in Acute Myeloid Leukaemia
Author(s) -
Ernst Peter,
Andersen Vagn,
Killmann SvenAage
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb02667.x
Subject(s) - extracorporeal , mitotic index , myeloid leukaemia , bone marrow , mitosis , myeloid , medicine , cell , cell cycle , blood cell , cancer research , immunology , biology , microbiology and biotechnology , biochemistry , cancer
A patient with acute myeloid leukaemia was treated with extracorporeal irradiation of the blood. During the irradiation, the blood blast cell count decreased considerably. Bone marrow studies showed an increase of the 3 H‐thymidine labelling index and particularly of the mitotic index within 8 hours after start of treatment; possible mechanisms of this are discussed. The rises in indices were moderate, however, and it remains to be seen whether such cytokinetic perturbations are large enough to allow definite therapeutic exploitation.