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Atypical Pyruvate Kinase in a Patient with Haemolytic Anaemia
Author(s) -
Brandt N. J.,
Hanel H. K.
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb01963.x
Subject(s) - pyruvate kinase , pkm2 , biochemistry , pyruvate kinase deficiency , enzyme , chemistry , thermostability , biology , glycolysis
In a case of hereditary nonspherocytic haemolytic anaemia an atypical erythrocyte pyruvate kinase was found. The pyruvate kinase was characterized as atypical on the basis of the following biochemical parameters which differed from those of the normal enzyme: Michaelis' constant, thermostability, pH dependency, urea inhibition, and electrophoretic mobility. The results indicate that there may be a structural difference between the atypical and normal pyruvate kinase.