Premium
Comparison of Thrombotest and Simplastin A (a Modified P & P Test) in the Detection of Prolonged Clotting Times of Whole Blood and Plasma During Anticoagulant Therapy
Author(s) -
KorsanBengtsen Kristoffer
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb00886.x
Subject(s) - clotting time , thromboplastin , medicine , partial thromboplastin time , whole blood , blood clotting , serial dilution , pharmacology , prothrombin time , chemistry , coagulation , pathology , alternative medicine
Methods used to control dicumarol therapy differ in their sensitivity to the inhibitor formed during administration of dicumarol. For this reason the therapeutic levels vary, even when the methods are standardized with the same dilutions of normal plasma. The problem investigated is whether prolonged clotting times of whole blood or plasma are heralded equally well by Thrombotest, which is sensitive to the inhibitor, as by Simplastin A (a modified P & P method), which is insensitive to it. Whole blood clotting time was determined for 130 patients, recalcification time of plasma in silicone‐treated tubes for 176 patients, and activated partial thromboplastin time for 350 patients. Thrombotest and Simplastin A were carried out simultaneously with the other tests on every patient treated with dicumarol. Thrombotest and Simplastin A did not differ in their ability to warn against prolonged clotting times of whole blood or plasma.