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Erythrophagocytosis in the Rat Bone Marrow Following Transfusion of Heat‐Denatured Erythrocytes
Author(s) -
Marton F.
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb00882.x
Subject(s) - bone marrow , phagocytosis , spleen , pathology , parenchyma , cytoplasm , chemistry , biology , medicine , immunology , microbiology and biotechnology
Observations of erythrophagocytosis in the human bone marrow have called attention to the bone marrow as an erythroclastic organ. In order to elucidate the erythroclastic potential of the rat bone marrow, female rats were transfused with heat‐denatured erythrocytes and killed after 4 hrs. Methacrylate‐embedded bone marrow sections demonstrated erythrophagocytosis in macrophages and in cytoplasmic protrusions within bone marrow sinusoids, and in the nursing cells of the erythroblastic islands within the bone marrow parenchyma. Transfusion of 59 Fe labelled erythrocytes allowed study of the erythrocyte uptake in the bone marrow, liver, and spleen. Autoradiography confirmed phagocytosis of transfused, denatured erythrocytes in the bone marrow.