Premium
An Extra C Chromosome and Various Metabolic Abnormalities in the Bone Marrow from a Patient with Refractory Sideroblastic Anaemia
Author(s) -
Hellström Kjell,
Hagenfeldt Lars,
Larsson Agne,
Lindsten Jan,
Sundelin Pär,
Tiepolo Luciano
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb00878.x
Subject(s) - bone marrow , labelling , chromosome , thymidine , dna , biology , dna synthesis , population , uracil , precursor cell , pathology , microbiology and biotechnology , cancer research , chemistry , immunology , medicine , cell , biochemistry , environmental health , gene
A clinical, cytological and biological study of a 57‐year‐old man with a sideroblastic anaemia is presented. A large population of cells with 47 chromosomes and an extra C chromosome was found in the bone marrow cells but not in skin cells or lymphocytes. The concentration of uracil nucleotides in the bone marrow of the patient was increased. When incubated with 3 H‐thymidine the erythroblasts of the patient's marrow showed a low labelling index, A considerable number of early erythroblasts not incorporating thymidine had an intermediate DNA content indicating an arrest in DNA synthesis. A normal labelling index was recorded for the myelopoietic cells.