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Intrinsic Factor Activity of Stomach Preparations from Various Animal Species
Author(s) -
Hippe E.,
Schwartz M.
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb00876.x
Subject(s) - intrinsic factor , stomach , hamster , in vitro , pernicious anaemia , biology , antibody , guinea pig , toad , anatomy , endocrinology , biochemistry , immunology
Stomach preparations from 19 different animal species have been studied for intrinsic factor activity by applying the Schilling test in patients with pernicious anaemia, and by means of in vitro assay with antibody to human intrinsic factor. Stomach preparations from man, pig, cow, ferret, rabbit, rat, and hamster were able to promote vitamin B 12 absorption in the human intestine. The B 12 ‐binding ability of these preparations was inhibited by antibody to intrinsic factor. Gastric mucosa homogenate from guinea pig was ineffective in the patients but reacted with the antibody to intrinsic factor. Stomach preparations from dog, cat, chicken, toad, frog, black slug, edible snail, lobster, eel, plaice, and sea trout were all inefficacious with the Schilling test as well as with the in vitro assay.