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Chromium 51 Uptake as A Function of Platelet Age
Author(s) -
Tsukada Toshiyasu,
Steiner Manfred,
Baldini Mario G.
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb00875.x
Subject(s) - platelet , chromate conversion coating , chemistry , population , biophysics , medicine , chromium , biology , organic chemistry , environmental health
This investigation was supported by the U. S. Atomic Energy Commission Contract AT (30–1) 3590. It is known that chromate uptake by platelets is mediated by a bimodal transport mechanism with a diffusional and a saturable transport component. These models of uptake were studied in rat platelet cohorts of different age, obtained during the recovery phase of thrombocytopenia induced by specific hetero‐antibody. At low concentrations of chromate in the medium the saturable transport mechanism prevailed and was found to be markedly dependent on platelet age. Platelets one day or less in age accumulated more than twice the amount of randomly‐aged platelets. At high concentrations of chromate at which diffusional transport predominates, no difference in total chromate accumulation was noted in these two platelet populations. The inhomogeneous distribution of 51 Cr in a platelet population may have important bearing on the interpretation of platelet survival curves since by the generally employed labelling method, chromate concentrations are utilized well within the range in which saturable transport prevails and younger platelets are more heavily labelled than older ones.