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Enhancing Effect of Clofazimine (B663) on the Phagocytosis of Neutrophilic Leucocytes in Vitro
Author(s) -
Brandt L.
Publication year - 1971
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1971.tb00874.x
Subject(s) - clofazimine , phagocytosis , in vitro , phenazine , chemistry , microbiology and biotechnology , immunology , biology , biochemistry , leprosy
Phagocytosis in vitro of neutrophilic leucocytes from normals and patients with chronic myeloid leukaemia was enhanced in the presence of Clofazimine (B 663), a phenazine derivative. The positive effect was obtained by adding the substance in a crystalline form or in an alcoholic solution at low concentration. With high concentrations of Clofazimine the enhancement was less pronounced.