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Cobalamin and Folate in Burned Mice
Author(s) -
Lindstrand K.,
Nordén Å.,
Schildt B. E.
Publication year - 1970
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1970.tb01928.x
Subject(s) - methylcobalamin , cobalamin , folic acid , medicine , erythropoiesis , hydroxocobalamin , chemistry , physiology , vitamin b12 , gastroenterology , cyanocobalamin , anemia
Megaloblastic erythropoiesis has been observed in certain forms of trauma. In the present study, the effect of a standardized burn injury upon the content of cobalamin and folate was determined in mouse liver. The response of burned mice to treatment with methylcobalamin and folate was also assessed. Methyl‐tetrahydrofolic acid dropped significantly already within six hours after the injury and remained low for more than four days. The content of methylcobalamin in the liver also dropped dramatically within 24 hours after the burn injury and remained low for six days. Treatment with methylcobalamin did not reduce mortality rate. Folate treatment, on the other hand, reduced the death rate significantly.