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Do Platelets Enhance Thromboplastin —Induced Intravascular Clotting?
Author(s) -
Evensen Stein A.,
Jeremic Michael
Publication year - 1970
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1970.tb01925.x
Subject(s) - platelet , thromboplastin , fibrinogen , clotting factor , haemolysis , coagulation , disseminated intravascular coagulation , medicine , tissue factor , clotting time , partial thromboplastin time , plasmapheresis , immunology , chemistry , antibody
During intravenous infusion of homologous tissue thromboplastin in normal rabbits, nearly 60% of the platelets initially present disappeared, but this platelet injury and destruction did not enhance intravascular clotting. Thus, clotting was equally severe in normal animals and in animals made extremely thrombocytopenic (mean: 4,000/,μ1, range: 1,000–8,000/μl) by the alkylating agent busulphan; more than half of the circulating fibrinogen and about two thirds of factor V activity were consumed, accompanied by significant decreases in the levels of factors VII and IX. Haemolysis was observed secondary to clotting, but never the generalized Shwartzman reaction.