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Effect of Treatment with Combined Phenformin and Ethyloestrenol on the Coagulation and Fibrinolytic Systems
Author(s) -
Isacson Sune,
Nilsson Inga Marie
Publication year - 1970
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1970.tb01922.x
Subject(s) - phenformin , fibrinogen , coagulation , fibrinolysis , plasminogen activator , platelet , medicine , platelet adhesiveness , endocrinology , coagulation system , chemistry , pharmacology , platelet aggregation , metformin , insulin
Administration of 100 mg phenformin combined with 8 mg ethyloestrenol for 30 days to 9 healthy volunteers raised the fibrinolytic activity in the circulating blood, reduced the fibrinogen content and platelet adhesiveness. In addition, it increased the plasminogen content, decreased the α 2 ‐macroglobulin and increased the plasminogen activator content in the walls of the superficial veins. In the coagulation and fibrinolytic systems, then, the combined treatment produced changes tending to counteract the development of thrombosis.