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Diagnosis and Assessment of Bleeding Tendency in Chronic Liver Failure Using Three Simple Coagulation Tests
Author(s) -
Mannucci P. M.
Publication year - 1970
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1970.tb01915.x
Subject(s) - prothrombin time , partial thromboplastin time , bleed , medicine , coagulation , gastroenterology , coagulation testing , thromboplastin , bleeding time , surgery , platelet , platelet aggregation
Three simple one‐stage coagulation screening tests have been performed on the same samples of plasma from 65 patients with chronic liver failure of mixed aetiology. The mean values of the kaolin‐activated partial thromboplastin time, prothrombin time, and prothrombin and proconvertin time (‘P&P’ test) were all significantly different from normal, but the alteration was more marked for the last test than the first two (80% of cases with the prothrombin and proconvertin time compared with about 60% for the other two tests). The prothrombin and proconvertin time was also a better indication of a tendency to bleed than the other two tests.