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51 Cr‐Half Life Time of Heavy and Light Human Erythrocytes
Author(s) -
Brinke M. ten,
Regt J. de
Publication year - 1970
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1970.tb01911.x
Subject(s) - chemistry , ultracentrifuge , half life , chromatography , radiochemistry , biology , pharmacology , pharmacokinetics
Relatively heavy as well as relatively light human erythrocytes, obtained by ultracentrifugation of normal blood in dextran solutions of different density, were labelled with 51 Cr and re‐injected into the same normal individual. By measuring the radioactivity of the blood after different intervals, the moment was determined at which radioactivity in the bloodstream had diminished to 50% ( 51 Cr T1/2). The 51 Cr T1/2 of the relatively heavy erythrocytes proved to be shorter, and that of the relatively light erythrocytes proved to be longer than that of unfractioned samples submitted to similar processing. In addition the relaively heavy fractions showed a highly variable, early loss during the first 24 hours following re‐injection.