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Mitotic Activity of Circulating Atypical Lymphocytes
Author(s) -
Malacarne Paolo,
Dallapiccola Bruno
Publication year - 1970
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1970.tb01906.x
Subject(s) - mitosis , mononucleosis , in vitro , dna synthesis , biology , immunology , thymidine , dna , virus , virology , genetics
A proportion of circulating atypical lymphocytes present during the active phase of infectious mononucleosis has an high rate of H 3 ‐thymidine incorporation in vitro, but the relationship between DNA synthesis and mitosis in these elements is unclear. In order to appraise the problem, a series of patients with atypical circulating lymphocytes (cases with virus and bacterial infections, reaction due to massive blood transfusion, drug hypersensitivity, schizophrenia) has been studied. An increase of DNA synthetic activity in vitro has been observed, and an high incidence of spontaneous mitoses was detected by means of direct chromosome preparations, as compared to healthy controls. These observations can be regarded as further evidence of high proliferative potential of atypical lymphocytes.