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Effects of Some Chemicals on Blood Platelet Microtubules, Platelet Shape and Some Platelet Functions in vitro
Author(s) -
Behnke O.
Publication year - 1970
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1970.tb01878.x
Subject(s) - platelet , microtubule , chemistry , clot retraction , biophysics , in vitro , biochemistry , microbiology and biotechnology , platelet aggregation , biology , immunology
Human blood platelets were treated in vitro with various chemicals to test whether a chemical which affects microtubules (demecolcine) also affects platelet shape and platelet function (aggregation and contraction) and whether chemicals which affect platelet function (cyanide, monoidoacetate, cyanide plus monoiodoacetate, fluoride, Ouabain, N‐ethylmaleimide, Mersalyl, and cocaine) also affect platelet shape and platelet microtubules. It is concluded that an intact marginal bundle of microtubules is essential for the maintenance of platelet shape but intact microtubules are not essential for ADP‐induced platelet aggregation or for clot retraction.