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Slow Activation of Factor VIII by Thrombin and other Enzymes at Low Temperature
Author(s) -
ÖZgeAnwar Ayse H.
Publication year - 1970
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1970.tb01861.x
Subject(s) - thrombin , chemistry , enzyme , fraction (chemistry) , factor v , factor x , biochemistry , biophysics , chromatography , medicine , biology , immunology , platelet , thrombosis
The activation of factor VIII by thrombin and reptilase in human fraction I‐O is described. The evidence is presented showing the presence of factor VIII activity in the supernatant fluid of the thrombin treated fraction I‐O in the process of clot formation. Factor VIII activity is more stable at a low temperature (−2° C). The significance of these observations with regard to possible purification of factor VIII is discussed.