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Protein Abnormalities in the Cold Haemagglutinin Syndrome
Author(s) -
Harboe Morten,
Torsvik Harald
Publication year - 1969
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1969.tb01836.x
Subject(s) - globulin , titer , homogeneous , monoclonal , monoclonal antibody , gamma globulin , chemistry , antibody , biology , immunology , physics , thermodynamics
Eighteen patients were studied, selected only on the basis of a persistently elevated cold haemagglutinin titre. The concentration of γM‐globulin in the initial serum sample varied from 0.7–24.5 mg./ml. In all of 15 patients studied in detail, the cold haemagglutinin behaved as a monoclonal γM‐globulin. In two patients, a homogeneous γ‐globulin remained in the serum after absorption with red cell stromata in the cold. This was shown to be due to an additional monoclonal γG‐globulin without cold haemagglutinin activity. The protein pattern remained virtually constant in each patient throughout the observation period.