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The Development of Plasma Cells in Antigen Stimulated Rabbit Blood Lymphocyte Cultures
Author(s) -
Lamvik J. O.
Publication year - 1969
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1969.tb01819.x
Subject(s) - antiserum , blastoid , antibody , staining , antigen , biology , fluorescein , lymphocyte , microbiology and biotechnology , rabbit (cipher) , immunology , pathology , chemistry , fluorescence , medicine , physics , lymphoma , quantum mechanics , mantle cell lymphoma , statistics , mathematics
Cells with morphological appearance like that of plasma cells were found in sheep red cell (SRC) stimulated cultures containing blood lymphocytes from SRC immunized rabbits after more than one week's culturing. These cells were strongly pyroninophilic and showed cytoplasmatic fluorescence after staining with fluorescein conjugated goat antirabbit gammaglobulin antiserum. The results indicate that antibody producing plasma cells evolved from the proliferating blastoid cells in the cultures.