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Haemoglobin Sogn (β 14 Arginine) A New Haemoglobin Variant
Author(s) -
Monn E.,
Gaffney P. J.,
Lehmann H.
Publication year - 1968
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1968.tb01760.x
Subject(s) - arginine , leucine , red cell , heterozygote advantage , hemoglobin , chemistry , endocrinology , biochemistry , medicine , amino acid , gene , genotype
Among 3,000 Norwegian individuals two haemoglobin variants were found. One was a Haemoglobin D Punjab. The other was a new variant, Haemoglobin Sogn, in which leucine is replaced by arginine at the internally sited residue 14 of the β chain. The haemoglobin variant shows a slight heat instability. Heterozygotes for Haemoglobin Sogn show a small amount of free α chains in their haemolysates, but no Heinz bodies are present in their erythrocytes and they are clinically healthy.