Premium
Immunological Studies in a Case of Gold Salt Induced Thrombocytopenia
Author(s) -
Stavem Per,
Strømme Johan,
Bull Otto
Publication year - 1968
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1968.tb01747.x
Subject(s) - platelet , prednisone , immune thrombocytopenia , antibody , medicine , immunology , lytic cycle , bone marrow , in vitro , blood transfusion , chemistry , biochemistry , virus
A woman developed severe thrombocytopenia a few days after the 8th injection of sodium aurothiomalate. She was treated with BAL, prednisone and a fresh blood transfusion, and the platelet count came back to normal after about 2 weeks. At that time the bone marrow contained many megakaryocytes, and the platelet life span was nearly normal. These observations suggest that the thrombocytopenia was due to an immune mechanism, but in vitro techniques failed to detect lytic, agglutinating, complement binding, or radioactive aurothiomalate‐binding antibodies.