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Development of Immune Haemolytic Anaemia and Thrombocytopenia in a Chronic Biologic False‐Positive Reactor for Syphilis
Author(s) -
Sievers K.,
Lehtinen Marja,
Aho K.
Publication year - 1968
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1968.tb01746.x
Subject(s) - haemolysis , syphilis , immune thrombocytopenia , immunology , antibody , medicine , serology , immune system , avidity , hemagglutination , human immunodeficiency virus (hiv)
Report of a case of immune haemolytic anaemia and thrombocytopenia antedated by 19 years with biologic false positive serological reactions for syphilis and initially associated with an aplastic crisis. The erythrocytes were heavily sensitized with complement and weakly with γG globulin. In spite of elevated cold agglutinins, the patient had not experienced Raynaud's phenomenon and there was no abnormal cold haemolysis. Ultracentrifugation studies revealed a quality change in the Wassermann antibodies that roughly parallelled the development of the haemolytic disease.