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IgD‐Myelomatosis. Report of a Case
Author(s) -
DAMMACCO FRANCO,
BONOMO LORENZO
Publication year - 1968
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1968.tb01734.x
Subject(s) - bence jones protein , immunoglobulin d , gamma globulin , immunoglobulin light chain , hypergammaglobulinemia , serology , multiple myeloma , immunology , medicine , immunoelectrophoresis , myeloma protein , pathology , antibody , b cell
A case of IgD‐myeloma is described. Severe renal failure and chronic biliary disease were the main clinical features. The serum electrophoretic pattern exhibited a narrow‐banded myelomatous protein migrating in the fast gammaglobulin region, and an additional, rudimentary spike with gamma‐2 mobility. Bence Jones protein was detected in both serum and urine of the patient. The main M‐component was identified by immuno‐electrophoresis as belonging to the newly recognized IgD class. Light chain antigenic determinants of both the myeloma protein and the urinary Bence Jones protein were of type kappa. Relationships between chronic biliary‐tract disease and monoclonal gammapathies are briefly discussed. Moreover, the interest of the diclonal serological abnormality, resembling the IgD‐IgG type gammapathy, is emphasized.