Premium
Turnover of 57 Co‐labelled Vitamin B 12 ‐Transcobalamin II and Autologous 131 I‐labelled IgG in a Patient with Antibody to Transcobalamin II
Author(s) -
HOM B. L.,
OLESEN H.,
SCHWARTZ M.
Publication year - 1968
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1968.tb01725.x
Subject(s) - catabolism , antibody , chemistry , vitamin b12 , cyanocobalamin , endocrinology , vitamin , medicine , pernicious anaemia , dissociation (chemistry) , metabolism , immunology , biochemistry
In a pernicious anaemia patient with a circulating antibody to transcobalamin II (TC II), the plasma clearance of radioactive vitamin B 12 bound to TC II has been shown to be much slower (plasma half‐life 8.2 days) than in control subjects (plasma half‐life 0.7 days). Thus, the patient's high serum vitamin B 12 binding capacity and elevated serum vitamin B 12 are the result of decreased catabolism of TC II due to the presence of antibody. The turnover of the B 12 ‐TC II‐antibody complex was shorter than that observed for autologous 131 I‐labelled IgG (plasma half‐life 16.8 days). This difference is most likely due to dissociation of the complex.