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Coagulation and Fibrinolytic Studies in Normal Individuals During Diuretic Treatment with Furosemide
Author(s) -
Hilden M.,
Amris C. J.
Publication year - 1968
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1968.tb01720.x
Subject(s) - furosemide , diuretic , coagulation , fibrinolysis , fibrinogen , medicine , urokinase , plasmin , endocrinology , chemistry , biochemistry , enzyme
The purpose of the investigation was to elucidate possible changes in coagulation and fibrinolysis during induced dehydration with Furosemide in 11 normal individuals. The 7 were followed before and for 31/2–4 hours after 80 mg. Furosemide perorally, the last 4 were control patients examined similarly, but with placebo instead of Furosemide. The following changes were observed in all the test subjects: 1. Significant increase in the fibrinolytic activity of plasma euglobulin 11/2–2 hours after Furosemide. 2. Significant increase in plasminogen and fibrinogen concentration. 3. Slight, not significant, increase in urokinase inhibitor. No changes in plasmin inhibitor.