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The Influence of Dietary Fats on Plasma and Platelet Lipids and ADP Induced Platelet Thrombosis in the Rat
Author(s) -
Nordöy Arne,
Hamlin James T.,
Chandler Arthur B.,
Newland Hillery
Publication year - 1968
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1968.tb00867.x
Subject(s) - cottonseed oil , cottonseed , thrombosis , platelet , linseed oil , incidence (geometry) , coconut oil , medicine , saturated fat , endocrinology , zoology , chemistry , food science , biology , cholesterol , physics , optics
The relationship between the type and quantity of dietary fat and the incidence of adenosine diphosphate induced platelet thrombosis was studied in rats fed a 10 per cent and 40 per cent saturated fat diet, a 40 per cent fat diet including 8 per cent cottonseed oil and a 40 per cent fat diet including 8 per cent linseed oil. The diets were given for 24 hours or 5 to 6 weeks. Platelet thrombosis was induced in pulmonary capillaries, arterioles, and small arteries by the intravenous injection of ADP. No significant difference in the incidence of thrombosis was observed following a 24 hour feeding period. After a 5 to 6 weeks feeding period, animals given a 40 per cent saturated fat diet had a higher incidence of thrombosis than animals given a 10 per cent saturated fat diet. When the 40 per cent fat diet included cottonseed oil, the incidence of thrombosis due to a low dose of ADP was reduced. When linseed oil was included in the diet, the incidence of thrombosis was reduced when both a low and a high dose of ADP was given. Significant changes occurred in the fatty acid pattern of the plasma and platelet phospholipids in animals fed the diets for 5 to 6 weeks. The diets induced small changes in the quantity of the main plasma lipid fractions.