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Co 57 Vitamin B 12 Clearance Studies in Pernicious Anaemia
Author(s) -
Meyer Leo M.,
Osofsky Marvin,
Miller Inez F.
Publication year - 1967
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1967.tb01631.x
Subject(s) - clearance , pernicious anaemia , clearance rate , medicine , vitamin , intrinsic factor , endocrinology , vitamin b12 , urology
1 Clearance rate of intravenously administered radioactive vitamin B 12 in untreated pernicious anaemia patients is slow in 50 per cent of cases studied. 2 Administration of labelled vitamin B 12 bound to slow serum to ‘normal clearing’ pernicious anaemia subjects or to normal persons is followed by normal clearance rate. 3 Radioactive vitamin B 12 bound to normal serum is cleared at a normal rate in pernicious anaemia patients with slow clearance rate. 4 Radioactive vitamin B 12 bound to slow serum when mixed with normal serum in proportions of 1:1 or 1:0.5 is cleared at a normal rate in ‘slow clearing’ pernicious anaemia patients. 5 These studies suggest the presence of a ‘serum factor’ in normal serum and some patients with pernicious anaemia in relapse which enhances clearance of vitamin B 12 bound to ‘slow serum’.