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Response of the Bone Marrow of the Vitamin E‐Deficient Rabbit to Coenzyme Q and Vitamin E
Author(s) -
Ludwig Frederic C.,
Elashoff Robert M.,
Smith Jack L.,
Scholler Jean,
Farley Thomas M.,
Folkers Karl
Publication year - 1967
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1967.tb01630.x
Subject(s) - vitamin e , tocopherol , bone marrow , medicine , endocrinology , vitamin , antioxidant , cofactor , coenzyme a , biology , chemistry , biochemistry , enzyme , reductase
The effect of hexahydrocoenzyme Q 4 and of α‐tocopherol on the haemopoietic tissues of dystrophic rabbits on a vitamin E‐deficient diet has been studied. Animals receiving this diet supplemented with α‐tocopherol were still significantly subnormal compared with the pellet controls. The diet had a significantly depressive effect on bone marrow cell maturation and on myeloid precursor cell supply as well as on the growth rate. Both hexahydrocoenzyme Q 4 and α‐tocopherol elicited a limited biological response in the bone marrow at the dose level administered. Neither therapy produced a haematological response corresponding to the cellular levels found in the pellet control group. Animals on the vitamin E‐deficient diet disclosed typical muscular lesions. Both hexahydrocoenzyme Q 4 and α‐tocopherol had a beneficial effect on these muscular lesions. It is considered that the biological activity of α‐tocopherol is directly that of an antioxidant protecting the biosynthesis of coenzyme Q 10 and that of hexahydrocoenzyme Q 4 is essentially substitution for coenzyme Q 10 .