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The Effect of Dietary Folate Deficiency on the Synthesis of Methylcobalamin in the Chick
Author(s) -
Lindstrand K.,
Anderson B. B.,
Cowan J. D.,
Coates M. E.,
Hoffbrand A. V.
Publication year - 1967
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1967.tb01619.x
Subject(s) - methylcobalamin , vitamin b12 , endocrinology , medicine , folic acid , biology , vitamin b , cyanocobalamin , vitamin , chemistry , zoology
The ratio of liver methylcobalamin to total liver vitamin B 12 was estimated in a group of one‐week‐old chicks fed a folate‐free diet, and a group of three‐week‐old chicks fed a diet of insufficient folate content to allow normal growth but sufficient to delay mortality. The ratio in these groups was compared with those in control chicks fed a diet of adequate folate content. The ratio of liver methylcobalamin/total liver B 12 was significantly lower in the one‐week‐old chicks fed a folate‐free diet, than in their controls, but the ratios in the three‐week‐old chicks fed a diet of limited folate content and their controls were similar. The significance of these findings is assessed and possible explanations for the inconsistency between the findings in the two folate deficient groups are discussed.