Studies on the Macroglobulins of Human Serum IV: The Frequency of Light Chain Types K and L in Polyclonal and Monoclonal γM. | Zendy

Wollheim Frank A. | Zendy; Snigurowicz Jaroslaw | Zendy

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Studies on the Macroglobulins of Human Serum IV: The Frequency of Light Chain Types K and L in Polyclonal and Monoclonal γM.

Author(s) -

Wollheim Frank A.,

Snigurowicz Jaroslaw

Publication year - 1967

Publication title -

scandinavian journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 84

eISSN - 1600-0609

pISSN - 0036-553X

DOI - 10.1111/j.1600-0609.1967.tb01608.x

Subject(s) - polyclonal antibodies , kappa , immunoglobulin light chain , typing , lambda , monoclonal , microbiology and biotechnology , chain (unit) , combinatorics , mathematics , monoclonal antibody , immunology , biology , physics , genetics , antibody , optics , astronomy , geometry

125 M‐components of class γM in 123 sera have been typed with regard to light chain determinants K and L. The typing of most sera required initial isolation of 19 S‐fractions by thin layer gel filtration. 100 components were typed kappa and 25 lambda, giving a ratio of 4 to 1. Polyclonal γM from young adults contained kappa and lambda determinants in the ratio of 2 to 1. Possible explanations for this discrepancy are discussed.

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