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The Influence of Acute and Long‐Term Exercise on Adenosine Diphosphate‐Induced Platelet Thrombosis and Plasma Lipids in Rats Fed a 40 Per Cent Butter Diet
Author(s) -
Nordöy Arne,
Newland Hillery,
Hamlin James T.
Publication year - 1967
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1967.tb01605.x
Subject(s) - triglyceride , medicine , endocrinology , platelet , phospholipid , fatty acid , thrombosis , incidence (geometry) , cholesterol , adenosine diphosphate , chemistry , biochemistry , platelet aggregation , physics , membrane , optics
The present study was performed in order to determine whether acute or long‐term exercise would influence the tendency to platelet‐thrombosis and the level of the main plasma lipids. Rats given a 40 per cent butter diet for 7 weeks were exposed to acute and long‐term exercise on a treadmill; one group was not exercised. Except for an increase of the free fatty acids in acute exercised rats, no changes were found in total cholesterol, phospholipids, triglycerides and free fatty acids in the plasma. There was no difference in the incidence of ADP‐induced thrombosis among the three groups. Non‐fasting, non‐exercised animals had higher plasma phospholipid and triglyceride levels than fasting, non‐exercised animals. No difference in the incidence of thrombosis was found between fasting and non‐fasting animals. No relation could be established between the incidence of thrombosis and acute or long‐term exercise in the rat. Increase of triglyceride, phospholipid and free fatty acid levels in plasma with more than 100 per cent did not influence the incidence of ADP‐induced thrombosis.