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A Case of Haemolytic Anaemia Due to Pyruvate Kinase Deficiency
Author(s) -
Hanel H. K.,
Harvald B.,
Mor G.,
Christensen N.,
Deckert T.
Publication year - 1967
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1967.tb01598.x
Subject(s) - pyruvate kinase deficiency , haemolysis , pyruvate kinase , in vitro , hemolysis , biochemistry , enzyme , biology , chemistry , medicine , immunology , glycolysis
A case of non‐spherocytic haemolytic anaemia is presented. A subnormal pyruvate kinase activity in the patient's erythrocytes was demonstrated. The in vitro haemolysis of the patient's red cells could be corrected by addition of adenosinetriphosphate. Some family members had also depressed pyruvate kinase activity, without any other haematological abnormalities. The inheritance of the defect is discussed.