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The Ultrastructure of Eosinophilic Granulocytes in the Peritoneal Cavity of Rats Following Injection of Ferritin
Author(s) -
BRORASMUSSEN FREDE,
EGEBERG J.
Publication year - 1966
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1966.tb02370.x
Subject(s) - eosinophilic , phagocytosis , ferritin , peritoneal cavity , pathology , degranulation , ultrastructure , eosinophil , infiltration (hvac) , vacuole , chemistry , cytoplasm , immunology , medicine , anatomy , receptor , biochemistry , physics , asthma , thermodynamics
Electron microscopic studies were performed on eosinophilic granulocytes obtained from the peritoneal cavity of rats by peritoneal lavage using 50 ml physiological saline at varying times after intraperitoneal injection of ferritin. Ten minutes after the injection the cytoplasm of the eosinophilic leukocytes showed phago‐lysosome‐like inclusions containing ferritin. These inclusions were also present one hour after the injections of ferritin. The ferritin phagocytosis results in morphological changes of the eosinophilic granules, but not in degranulation of the eosinophilic cells. In the neutrophilic cells of the peritoneal fluid there were clusters of phago‐cytized eosinophilic granules exhibiting signs of degenerative changes. The phagocytosis of eosinophilic granules is interpreted as a link in the disintegration of the eosinophilic leukocytes.