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Drug‐Induced Malabsorption of Vitamin B 12 III. Interference of PAS and Folic Acid in the Absorption of Vitamin B 12
Author(s) -
Palva I. P.,
Heinivaara O.,
Mattila M.
Publication year - 1966
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1966.tb01435.x
Subject(s) - malabsorption , folic acid , vitamin , vitamin b , gastroenterology , vitamin b12 , medicine , excretion , absorption (acoustics) , malabsorption syndromes , chemistry , physics , acoustics
In 22 patients with lowered Schilling test values during treatment with PAS a new Schilling test was performed with folic acid (FA) as additive. In the 9 patients with original Schilling test values of less than 5 per cent the mean value rose from 3.7 to 7.2 per cent when FA was added. In the 13 patients with values of 5 to 9 per cent the mean excretion rose from 6.9 to 10.7 per cent. In 18 patients suffering from B 12 malabsorption for other reasons than PAS‐treatment the addition of FA failed to improve the Schilling test values. A competitive inhibition of FA is believed to be an important reason for PAS‐induced malabsorption of vitamin B 12 . It is further concluded that FA may play a role in the transport mechanism of B 12 through the intestinal wall.