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The Plasma Cells of the Bone Marrow in Myelomatosis Treated with Alkeran® (Melphalan)
Author(s) -
Axelsson Uno
Publication year - 1966
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1966.tb01433.x
Subject(s) - melphalan , plasma cell myeloma , bone marrow , nucleolus , plasma cell , multiple myeloma , medicine , chemistry , pathology , nucleus , psychiatry
The cytological appearance of the bone marrow was studied during Alkeran treatment of 46 patients with myelomatosis. The plasma cell count had decreased in 39 per cent, it remained unchanged in 48 per cent and was increased in 13 per cent. The plasma cell count seems to be of little value in the appraisal of the effect of treatment, especially compared with that of the concentration of the M component. The only qualitative change seen was a disappearance of the nucleoli from the plasma cells in 4 cases.