Premium
An Atypical Circulating Anticoagulant
Author(s) -
DOUGLAS A. S.,
CLATANOFF D. V.,
MCNICOL G. P.,
BAILEY P. A. M.
Publication year - 1966
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1966.tb00625.x
Subject(s) - serial dilution , thromboplastin , medicine , anticoagulant , prothrombin time , partial thromboplastin time , lupus anticoagulant , endocrinology , pathology , coagulation , thrombosis , alternative medicine
A male, aged 40 years of age, with severe hypertension and biological false positive Wassermann reaction was found incidentally to have a circulating anticoagulant with certain atypical features. The thromboplastin generation test at the standard dilutions was normal with control plasma as substrate, but abnormal when the patient's plasma was used as substrate. There was a prolonged one stage pro‐thrombin time not corrected by normal plasma. Prothrombin was deficient but the patient plasma did not destroy a normal plasma's prothrombin on incubation.