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Drug‐Induced Malabsorption of Vitamin B 12
Author(s) -
PALVA I. P.,
HEINIVAARA O.
Publication year - 1966
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1966.tb00623.x
Subject(s) - malabsorption , intrinsic factor , vitamin b , vitamin , stomach , medicine , chemistry , absorption (acoustics) , drug , intestinal malabsorption , endocrinology , small intestine , malabsorption syndromes , gastroenterology , pharmacology , physics , acoustics , coeliac disease , disease
The present paper describes dialysis tests of rat stomach and bowel extract to show the effect of PAS on the various stages of vitamin B 12 absorption. According to the results, PAS does not inhibit the formation of IF nor interfere with the binding of vitamin B 12 to the IF that has formed. Nor does PAS inhibit origination of the “releasing factor” in the wall of the rat intestine. The “releasing factor” releases B 12 from the IF complex also in the presence of PAS. This finding supports the view that the PAS‐induced malabsorption of vitamin B 12 is based on inhibition of the enzyme system by means of which B 12 normally penetrates the bowel wall.