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Development and Possible Significance of Abnormal Cell‐Lines in the Acute Stage of Chronic Myelogenous Leukaemia
Author(s) -
Pedersen Bent
Publication year - 1965
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1965.tb01292.x
Subject(s) - karyotype , stage (stratigraphy) , bone marrow , cytotoxic t cell , biology , disease , pathology , immunology , mitosis , medicine , oncology , cancer research , genetics , chromosome , in vitro , paleontology , gene
“Families” of closely related, abnormal karyotypes were found in mitoses from bone marrow and cultured leucocytes in four cases of chronic myelogenous leukaemia in the acute stage of the disease. The development of such karyotype families seems to coincide with clinical relapses which are fatal in the course of a few months. It is probable that cells with different karyotypes have different viability in the leukaemic organism. Consequently, in patients treated with cytotoxics, those karyotypes are likely to be selected which are less sensitive to the cytotoxics applied. If this hypothesis is correct, it may contribute to an explanation why patients controlled for years with certain cytotoxic drugs, suddenly grow refractory to these agents.