Premium
Antigenic Heterogeneity of Waldenström Type γM‐Globulins
Author(s) -
Harboe M.,
Deverill J.,
Godal H. C.
Publication year - 1965
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1965.tb01289.x
Subject(s) - globulin , antigen , gamma globulin , antiserum , immunology , antibody , immunization , chemistry , macroglobulinemia , medicine , multiple myeloma
By immunization of rabbits with isolated γM‐globulin from patients with Waldenström's macroglobulinaemia and absorption with normal serum, an antiserum was obtained (R 112) that precipitated sera from some, but not all, patients with Waldenström's macroglobulinaemia. The antigen was localized to the heavy polypeptide chain of the γM‐globulin molecule. A similar heterogeneity was suggested in normal γM‐globulin.