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Adhesiveness to Glass and Phagocytic Activity of Neutrophilic Leukocytes in Myeloproliferative Diseases
Author(s) -
Brandt Lars
Publication year - 1965
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1965.tb01288.x
Subject(s) - polycythaemia , leukocytosis , phagocytosis , medicine , myeloproliferative disorders , immunology , peripheral blood , polycythemia vera , myeloid , macrophage , polycythemia rubra vera , pathology , biology , biochemistry , in vitro
In chronic myeloid leukaemia the adhesiveness of mature neutrophilic leukocytes to an approximately standardized glass bead column and the phagocytic activity of neutrophils are abnormally low. The distribution of neutrophils with different power of phagocytosis has been investigated in 6 cases of CML. The increasing number of white blood cells characteristic of aggravation of the disease is accompanied by an increasing part of mature neutrophils with low phagocytic activity. Neutrophils with high phagocytic activity do not change their number to any extent in different stages of CML. Nor does this number seem to be significantly higher in CML than in normals. Neutrophils in 3 cases of polycythaemia vera with leukocytosis, 1 case of thrombocythaemia with leukocytosis and 2 cases of 32 P‐treated polycythaemia vera with signs of acute leukaemia had a high phagocytic activity. One case of myeloproliferative disorder originally diagnosed as polycythaemia vera with certain later signs of CML had a phagocytic pattern similar to that seen in typical cases of CML.